Preserving the TME

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An innovative approach using fresh patient biopsies

Elephas has developed a platform that utilizes fresh patient biopsies to preserve the tumor microenvironment (TME) for evaluation of immunotherapy response. The CybridPrep process prepares these biopsies using proprietary instruments to cut and encapsulate them before assessment on the Elephas platform.

The tumor microenvironment: Complexity that can’t be re-created

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The tumor microenvironment includes various cell types in a distinct extracellular matrix. The interaction among tumor, noncancerous, and immune cells can create an immunosuppressive environment that promotes tumor progression.

The complex interactions within the tumor microenvironment impact tumor formation, drug resistance, and immunotherapy response. These interactions are essential for understanding immunotherapy activity and how it will translate to patient response. Without preserving the tumor microenvironment, response prediction becomes a challenge.

PRESERVING THE TUMOR MICROENVIRONMENT STARTS WITH SPECIMEN PREPARATION

The unique CybridPrep process prepares the live biopsy for baseline and immunotherapy response assessment through proprietary cutting and encapsulation methods. These tools protect the native 3-dimensional cellular architecture and tumor microenvironment to enable the second step in the process, CybridScope.

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