Preserving the tumor microenvironment
Elephas’ advanced imaging technology, CybridScope, is used to visualize the viability of the live tumor.
Preserving the tumor microenvironment
Assessing the tumor with advanced imaging
Delivering data via secure, cloud-based portal
Our technology and world-class team put Elephas at the frontier of advanced clinical imaging capabilities. Advanced imaging is central to our approach because the amount of tissue from a biopsy is small and heterogeneous in content and cellularity. Our advanced imaging technology nondestructively images 3D tissue structures and allows for data capture at multiple time points (i.e. over 48-72 hours) while maintaining the tumor microenvironment. This data, along with cytokine profiles and tumor content analysis, informs the prediction of patient response to immunotherapy.
Elephas is the only company to combine multiple advanced imaging techniques into one proprietary instrument. These tools have the capability to unlock novel insights into the tumor microenvironment.
Dynamic optical coherence microscopy (dOCM) is used for real-time, in-depth analysis of live tissue. With dOCM, the biological impact of drugs can be observed with speed and precision. This non-destructive technique generates high-resolution views of tissues, making it a useful tool for understanding viability over time ex vivo.
Multiphoton microscopy (MPM) enables deep tissue penetration with minimal disruption to live cells. This proprietary technology is crucial for observing intricate biological processes and evaluating drug efficacy within live tissue structures.
Multiphoton fluorescence lifetime imaging microscopy (MP-FLIM) enables non-destructive longitudinal assessment of drug agents in intact tumor tissue without the use of disruptive probes, the Elephas approach is a label-free method to quantify the health of individual cells in biopsied tumor tissue.
MPM: Two fields of view from the same tumor, demonstrating the heterogeneity inherent in tumors.
Cas-Green (detects apoptosis); CD8 (T cell); NAD(P)H (metabolism); SHG (extracellular matrix/collagen)