Prepare
Preserving the tumor microenvironment
The Elephas Live™ platform will predict response to therapy by measuring live biopsies' viability, tumor content, and cytokine secretion over time using a series of proprietary assays and instruments.
Core needle biopsies present a unique challenge for live tissue analysis due to their small size and the high degree of heterogeneity both within and between specimens, even from the same tumor. Recognizing this limitation, the Elephas team leveraged the platform's ability to keep tissue alive to develop a novel method: each well in a well-plate functions as its own control and treatment arm. This innovative approach ensures robust and reliable detection of ex vivo responses to therapy, overcoming a significant barrier that has hindered similar systems in the past.
At the heart of the Elephas Live™ platform is our advanced imaging technology, Elephas Live Vista™: a breakthrough designed to assess tissue viability without damaging the specimen or interfering with downstream assays. Unlike anything else on the market, advanced imaging offers repeatable and reliable insights into the viability status of live tissue samples and is operational today. Beyond viability assessment, we designed the platform with imaging at its core to lay the groundwork for future innovations. The exceptionally high-resolution, large field-of-view imaging capabilities of Elephas Live Vista™ will enable Elephas to unlock transformative insights through artificial intelligence and machine learning. These could include advancements such as 3D cell segmentation, subcellular structure imaging, and even the potential to predict therapeutic responses using imaging alone.
Elephas is developing a novel technology that detects tumor content within biopsies using a microwave signal probe. This innovative technology aims to replace traditional diagnostic staining in our process by determining the dielectric status of tissue — a characteristic shown in scientific literature to differ significantly between malignant and benign tissue. While current approaches utilize this technology in vivo, Elephas is pioneering its adaptation for ex vivo use. This novel data type has the potential to feed future algorithms, further enhancing the platform’s ability to predict therapeutic responses.