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First-in-class assay that measures immune response in live tissue

Immunotherapies have transformed cancer care. However, the lack of reliable predictive biomarkers makes it challenging to determine which patients will benefit from these powerful treatment options.

To maximize the potential for immunotherapies to improve the lives of those affected by cancer, Elephas developed elive™ — an ex vivo platform that enables functional profiling of live tumor tissue for real-time immunotherapy response prediction.

Uses live tumor tissue from a core needle biopsy as small as 20-gauge
Employs a precision cutting tool to create consistent, viable live tumor fragments
Maintains large, contiguous sections of native tumor microenvironment using novel hydrogel
Controls for tumor heterogeneity using a patented sequential treatment strategy
Functional assessment of ICI treatment via cytokine analysis
Includes positive control to confirm tissue viability

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Step One: Prepare

Within 24 hours of biopsy collection, the core needle biopsy is cut into fragments. Those fragments are encapsulated in a hydrogel that supports cell viability.

elive™ Edge is a fully automated cutting instrument that precisely slices the biopsy into uniform live tumor fragments. Read more about Edge.

elive™ Gel is a proprietary hydrogel that preserves tissue architecture and cellular viability. Read more about Gel.

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Step Two: Assess

elive™ Method applies control and treatment conditions to live tumor fragments in the same well using a phased approach. Cytokine profiling is performed at defined time points to assess response to immunotherapy. This approach mitigates the challenges of intratumor heterogeneity, and the low tissue yield from core needle biopsies. Read more about Method.

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Step 3: Result

Clinicians receive elive Test reports via a secure, cloud-based web application.

Researchers and drug developers receive a custom report based on project requirements. In addition to a report summarizing key findings, we provide raw data to facilitate in-house analysis.