Clinical Trials

Our Clinical Trials

We are conducting multiple observational clinical trials. The primary objective of these trials is to determine the ex vivo predictive accuracy of elive™ across a variety of solid tumors. Learn more about our current and completed trials below.

Study endpoints:

  • Sensitivity and specificity of Elephas platform for predicting clinical response to immune checkpoint inhibitors
  • Compare to existing FDA approved biomarkers (PD-L1, MSI, MMR and TMB)
  • Compare between predicted responders and non-responders (ORR, DCR, PFS, OS)

Measured per RECIST v1.1 and iRECIST

Proud to be working with

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Current Trials

ELEPHAS-04: Mayo Clinic

Mayo Clinic MC230901: Observational Basket Trial to Collect Tissue to Develop and Train and Validate a Live Tumor Diagnostic Platform

Tumor types: Bladder cancer, Colorectal cancer, Endometrial cancer, Head & neck cancer, Kidney cancer, Liver cancer, Melanoma, Non-small cell lung cancer, Triple negative breast cancer, Esophageal cancer, Cervical cancer

Read the press release »

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Setting:

Metastatic & recurrentAdvancedNeoadjuvantAdjuvant

Complete study details: NCT06349642

ELEPHAS-05

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies 

Observational Trial to Collect Tumor Tissue and Clinical Data From Patients Undergoing Biopsy for Suspected or Confirmed Cancer to Characterize Ex Vivo Response to Immunotherapy 

Tumor types: Bladder cancer, Triple negative breast cancer, Colorectal cancer, Endometrial cancer, Head & neck cancer, Kidney cancer, Liver cancer, Non-small cell lung cancer, Melanoma 

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These trials will provide an opportunity to demonstrate correlation between ex vivo and clinical response to immunotherapy regimens.

Closed Trials

ELEPHAS-01: Lung Trial

Observational Lung Trial to Collect Tissue to Train and Validate a Live Tumor Diagnostic Platform

Tumor types: Non-small cell lung cancer

Setting:

Metastatic & recurrent

Complete study details and locations: NCT05478538

ELEPHAS-02: Basket Trial

Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform

Tumor types: Bladder cancer, Colorectal cancer, Endometrial cancer, Head & neck cancer, Kidney cancer, Liver cancer, Melanoma, Non-small cell lung cancer

Setting:

Metastatic & recurrentAdvanced

Complete study details and locations: NCT05520099

Clinical Trial Design

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We are enrolling over 600 patients in our studies.

Hospitals and academic research centers within the US provide consented patient specimens.

If you are a physician or researcher, contact us to learn more.